Meredith Clark, Ph.D.

Dr. Clark is responsible for monitoring the formulation development and preclinical testing of pipeline products for Product Development at CONRAD. The scope of projects she helps oversee includes the development of intravaginal rings and combination gels, and the in vivo and in vitro evaluation of pharmacokinetics and safety for these and other pipeline products. Dr. Clark received her B.S. in Neurobiology, Physiology and Behavior from the University of California, Davis in 2001 and her Ph.D. in Bioengineering from the University of Utah in 2008.  She has been an active researcher in the microbicides field for several years, beginning with her dissertation work on the development of in situ gelling formulations for enhanced microbicide gel deployment and retention.  Dr. Clark joined CONRAD in 2009 as Manager, Drug Delivery. She is also an Assistant Professor in the Department of Obstetrics and Gynecology at Eastern Virginia Medical School.

Publications

• Multipurpose prevention technologies: biomedical tools to prevent HIV-1, HSV-2, and unintended pregnancies
• Enzymatic triggered release of an HIV-1 entry inhibitor from prostate specific antigen degradable microparticles
• Ethylene vinyl acetate intravaginal rings for the simultaneous delivery of the antiretroviral UC781 and contraceptive levonorgestrel
• Pharmacokinetics of UC781-loaded intravaginal ring segments in rabbits: a comparison of polymer matrices
• Preclinical evaluation of UC781 microbicide vaginal drug delivery
• Recent Trends in Microbicide Formulations
• Preclinical evaluation of anti-HIV microbicide products: New models and biomarkers
• Design of a semisolid vaginal microbicide gel by relating composition to properties and performance
• Temperature and pH sensitive hydrogels: an approach towards smart semen-triggered vaginal microbicidal vehicles